Most children with don’t need treatment. Hemoglobin is the protein in red blood cells that carries oxygen to cells throughout the body. Normally, people have four genes for alpha globin with two genes on each chromosome (αα/αα). Missing four genes (Hydrops fetalis): (--/--), this is a life threatening disease. protein chain. Establishing the diagnosis of the α-thalassemia trait requires measuring either the α-β chain synthesis ratio or performing genetic tests of the α globin cluster - eg, using polymerase chain reaction (PCR) assay tests. Alpha thalassemia trait is characterized by two functional genes that code for the production of alpha globins [(-α/-α) or (--/αα)]. There are two different types of alpha thalassemia trait. Alpha thalassemia trait Minor anemia 3 Hemoglobin H disease Mild to moderate anemia may lead normal life 4 Hydrops fetalis Fetal death usually occurs at birth Beta-thalassemia. Alpha thalassemia occurs when the body can’t make alpha globin. Silent alpha thalassemia carriers have no signs or symptoms of the disease, but are able to pass thalassemia on to their children. We continue to provide in-person care and telemedicine appointments. Daily doses of folic acid, a vitamin vital to hemoglobin production. A DNA test is needed to make a diagnosis of alpha thalassemia. Outside the newborn period, it is not possible to make this diagnosis by conventional methods. Missing one alpha thalassemia gene (silent carriers): (αα/α-), a silent carrier does not have any symptoms. Being a silent carrier means you don’t have signs of the disease, but you can pass the damaged gene on to your child. Alpha Thalassemia Trait (2 genes affected). This is caused due to the absence or the inactivity of one or two copies of the alpha globin gene. Two genes are missing. The trans form of alpha thalassemia trait (α-/α-) is common in African-Americans (20-30%) and in people of African descent. This test checks the size, number, and maturity of different blood cells in a set volume of blood. You may also have an enlarged liver or spleen, yellowish skin, and leg ulcers. Blood transfusions, if hemoglobin levels drop suddenly . People who have alpha thalassemia trait have red blood cells (RBCs) that are smaller ( microcytic ) and paler ( hypochromic ) than normal, have a decreased MCV (mean corpuscular volume, a measurement of the average size … One gene is missing or damaged, and the other 3 are normal. The two types are alpha thalassemia and beta thalassemia. Alpha thalassemia minor and beta thalassemia minor, also known as alpha thalassemia trait or beta thalassemia trait, are common conditions in many demographics. Alpha thalassemia trait: Introduction. The trans form of alpha thalassemia trait (α-/α-) is commonly found in African-Americans (20-30%) and in people of African descent. When the two alpha globin genes lost are on the same chromosome 16 is called cis , but when one alpha globin gene is missing on each copy of chromosome 16 this is called trans . Common symptoms for each type may include: Silent alpha thalassemia carrier. Alpha thalassemia affects the amount of hemoglobin in the red blood cells. Beta thalassemia major is also known as Cooley’s anemia. Alpha thalassemia genes can mix in different ways; this can range from the loss of one alpha thalassemia gene to the loss of four alpha thalassemia genes. There are two different types of alpha thalassemia trait. Children with this condition may have red blood cells that are smaller than normal (microcytosis) … This causes severe anemia. Alpha thalassemia trait may come to the attention of doctors in one of two ways: 1) By newborn screening with Hemoglobin Barts as in this baby’s case. The patient should be screened first by requesting a CBC and Hemoglobin Electrophoresis. 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